A novel anti-virulence compound for combat associated infection

David Anderson, Stephen Barnes, Hao Li, Hongmin Sun. Orlando, FL, August 27-30, 2017

 

Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice.

Sun H, Xu Y, Sitkiewicz I, Ma Y, Wang X, Yestrepsky BD, Huang Y, Lapadatescu MC, Larsen MJ, Larsen SD, Musser JM, Ginsburg D.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74. doi: 10.1073/pnas.1201031109. Epub 2012 Feb 13.

PMID: 22331877

 

A novel approach to develop anti-virulence agents against group A streptococcus.

Xu Y, Ma Y, Sun H.

Virulence. 2012 Aug 15;3(5):452-3. doi: 10.4161/viru.21039. Epub 2012 Aug 15. No abstract available.

PMID: 23076247

 

Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation.

Ma Y, Xu Y, Yestrepsky BD, Sorenson RJ, Chen M, Larsen SD, Sun H.

PLoS One. 2012;7(10):e47255. doi: 10.1371/journal.pone.0047255. Epub 2012 Oct 15.

PMID: 23077578

 

Novel inhibitors of bacterial virulence: development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression.

Yestrepsky BD, Xu Y, Breen ME, Li X, Rajeswaran WG, Ryu JG, Sorenson RJ, Tsume Y, Wilson MW, Zhang W, Sun D, Sun H, Larsen SD.

Bioorg Med Chem. 2013 Apr 1;21(7):1880-97. doi: 10.1016/j.bmc.2013.01.046. Epub 2013 Feb 1.

PMID: 23433668